Welcome to the Butovsky Lab

Alzheimer’s disease (AD) is the most prevalent form of senile dementia and affects 4.5 million Americans. In our lab, we research the role of microglia in AD. Microglia are cells within the central nervous system which we might refer to as the “big eaters”; they play an important role in the maintenance of the brain’s condition in health and disease. Through our projects, we seek to understand the different subsets of microglia within the AD brain and why they seem to be unable to efficiently clear out the amyloid plaques that build up during AD onset. We focus on certain genetic risk factors, such as apoliprotein E (APOE) and TREM2, and their involvement in microglia regulation and function. We use a combination of in vivo studies utilizing transgenic mouse models as well as human specimens with goal of finding new potential targets for treatment.

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