I was born and brought up in Nigeria, where I obtained my first degree in pharmacy. I practiced for some years, gaining work experiences in pharmaceutical industry as well as retail pharmacies. In 2013, I moved to the United States to attend graduate school at University of South Carolina, where I received my master of public health (MPH) and recently completed my PhD in pharmaceutical sciences. For my PhD research, I was part of a neuropharmacology/addiction genetics lab, where I specifically studied the role of microglia in nicotine dependence. This research exposed me to the world of microglia, which I found very fascinating. My interest and motivation to continue studying the role of microglia in health and disease led me to the Butovsky lab, where I will be investigating cross-talks between monocytes and microglia in Alzheimer’s and Multiple Sclerosis. At my leisure, I enjoy playing football, and sometimes tennis.
I completed my Medical Degree at University of Milan, Italy and always wanted to investigate amyotrophic lateral sclerosis (ALS). I joined the Butovsky lab at Brigham and Women’s Hospital/Harvard as a post-doc research fellow in 2015 to research the interaction between the immune system (both central and peripheral) and ALS. Specifically, I am investigating the mechanism of regulation of innate immunity in ALS and major immunomodulatory molecules expressed by microglia as targets to treat ALS. We recently identified a new mechanism mediated by TREM2-APOE signaling, which induces neurodegenerative microglia in a mouse model and human ALS. We also established an ongoing collaboration with Merit Cudkowicz and her team at the ALS clinic at MGH. This collaborative effort led to the hypothesis that peripheral immune cells have an informative molecular signature that can be used to monitor disease onset and progression and may serve as a potential target for immune-modulation in ALS. We therefore initiated a new NIH funded study to characterize the nature and timing of immune system perturbations in ALS, defining the immune cells that show the earliest and most profound changes.
I can describe my research interest with one word: Microglia. Microglia, the brain-resident macrophages and phagocytes, most sexually dimorphic glia cells in the brain and they are recently appreciated as novel therapeutic targets in many neurodegenerative diseases. During my Ph.D. in Prof. Helmut Kettenmann’s lab, I studied differences in male and female microglia in many aspects and improved my knowledge about their role in many different disease conditions, which lead me to pursue as a Postdoctoral fellow in Dr. Butovsky’s lab. Here, I will be focusing on the modulation of microglia as a therapeutic approach in different neurodegenerative diseases, mostly Alzheimer Disease and Multiple Sclerosis. Outside the lab, I enjoy travelling and yoga.
I was born and raised in South Florida. Moving slightly north, I attended the University of Florida where I received my B.Sc. and Ph.D. in Biomedical Engineering. During my doctoral work, I studied the relationship between epilepsy and neurogenesis, cognition, and neuroinflammation. This was my first introduction to neuroimmunology, and importantly, to microglia. Their wide array of roles ranging from mediating immune responses to maintaining homeostasis and synaptic remodeling instantly captured my imagination. My interest in the field only grew as microglia emerged as therapeutic targets in neurodegenerative and neuroinflammatory diseases. This interest has lead me to the Butovsky lab, where I will be focusing on the role of microglia and recruited monocytes in multiple sclerosis. Outside of the lab, I enjoy reading fiction novels, tennis, and playing with my dog, Piper.
My research interests focus on the immunomodulation of microglia during brain development and neuroinflammation, via genetic and/or environmental cues. I started to study Neurobiology at Limoges and Bordeaux Universities in France. During my Ph.D. studies at Bordeaux University, I focused more on Neuroimmunology when I joined the lab of Dr. Laye. I developed a great interest in microglia (my favorite cell) at that time. I looked at the effects of lipid maternal nutrition (omega3 deficiency during gestation) on microglia modulation and functions during brain development. For my postdoctoral research, I joined Dr. Butovsky’s lab to study microglia (still my favorite cell) and how they are immunomodulated in neurodegenerative diseases. We identified a novel mechanism of microglia modulation in disease, mediated by TREM2-APOE signaling. As a continuation, I recently started to investigate the effects of stress and neglect on microglia during early brain development and how these immune consequences can contribute to the appearance of early onset of neurodegenerative diseases such as Alzheimer’s disease.
I was born and grew up in Croatia. I moved to the United States to attend college in California, and stayed there for my subsequent medical training. I completed my B.S., M.D., and Ph.D. training at Stanford, where my Neuroscience Ph.D. focused on mechanisms of synaptic specificity and neuronal polarity in C. elegans. I completed my ophthalmology residency and glaucoma fellowship at Duke, and then joined the faculty of Massachusetts Eye and Ear Infirmary/Harvard Medical School. As a Harvard-Vision Clinical Scientist Development Program (K12) scholar, I am spending 25% of my time on clinical activities (ophthalmology clinic and surgery) and 75% of time on developing a research enterprise in the Butovsky lab, with the ultimate goal of becoming an independent investigator. I am particularly interested in the role of the innate immune system in the pathogenesis of glaucoma. During my K12 training I am planning to investigate the role of microglia in mouse models of glaucoma, with the ultimate goal of developing new therapeutic modalities for this common blinding disease. In my free time, I enjoy spending time with my family, traveling, going to restaurants and museums, and dancing.
I was born in Wuhu, a beautiful city sitting on the southeast bank of Yangtze River in China. After receiving the M.D. in China, I pursued the Ph.D. in neuroscience at the University of Groningen in the Netherlands. I am interested in unveiling the regulation of microglia phenotypes in the healthy and diseased brain, as a way to understand how our brains react to aging, neurodegeneration and altered environments. Currently, I am investigating the regulating pathways of microglia under various disease conditions, e.g., Alzheimer’s disease, delirium, to understand the alterations of microglia physiology and Ab pathology in diseases, which may lead to novel therapeutic approaches. In my spare time, I enjoy jogging, traveling and visiting museums.
I grew up in Montague, MA and graduated from Kenyon College in 2018 with a B.A. in Neuroscience. While at Kenyon, I was a member of the Petersen Lab and worked on a project investigating the pathways by which pharmacological therapeutics can enhance myelination in zebrafish. In the Butovsky lab, I work mainly with Dr. Margeta studying the role of microglia in the pathogenesis of glaucoma. In my free time, I enjoy traveling, hiking, and trying out new recipes.
I grew up in the town of Andover, MA. In 2019, I graduated from Princeton University with a B.A. in Ecology and Evolutionary Biology as well as a certificate in Global Health and Health Policy. At the Butovsky Lab I work with Zhuoran Yin and Jeffrey Leibowitz looking at the many roles and regulating pathways of microglia in Multiple Sclerosis and Alzheimers. During my free time, I enjoy cooking, hiking with my dogs and going to the beach.
I grew up in Bar Harbor ME and graduated from Skidmore College in 2018 with a B.A. in Biochemistry and a minor in Anthropology. At Skidmore I was a member of the Sheppard Lab and studied the specificity of non-discriminating asparaginyl-tRNA synthetase in a number of bacterial models. In the Butovsky lab, I am a Research Assistant working closely with Dr. Calcagno examining the interaction of the immune system with ALS. I like to spend my free time outside, traveling, and with friends.
I was born and raised in Upstate New York. In 2019, I graduated with my B.S. in Chemical and Biomolecular Engineering from the Johns Hopkins University. At Hopkins, I worked in the Kannan Lab and utilized a dendrimeric nanoparticle to deliver small molecule drugs to manipulate activated microglia after intravenous administration in multiple animal models, including a Parkinson’s disease model. I then started my Ph.D. with the joint Harvard-MIT Health Sciences and Technology, Medical Engineering and Medical Physics Ph.D. program, as an NSF GRFP Fellow. During my Ph.D., I plan to continue working to manipulate microglia, with the goal of developing a therapeutic for patients with neurodegenerative diseases. Outside of the lab I enjoy skiing, playing basketball and football, and exploring the mountains and parks of the northeast with friends and family.
I was born in Boston and grew up in Andover Massachusetts. I currently attend GeorgetownUniversity where I study neurobiology. At Georgetown, I work in the Huang Lab and studyOligodendrocytes and remyelination in Multiple Sclerosis. I am working in theButovsky lab thissummer as a Research Trainee. In my free time, I like to play guitar, sail, and be with my friends.