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2019

Okunuki, Y., Mukai, R., Nakao, T., Tabor, S. J., Butovsky, O., Dana, R., … & Connor, K. M. (2019). Retinal microglia initiate neuroinflammation in ocular autoimmunity. Proceedings of the National Academy of Sciences116(20), 9989-9998.

Zrzavy, T., Höftberger, R., Berger, T., Rauschka, H., Butovsky, O., Weiner, H., & Lassmann, H. (2019). Pro‐inflammatory activation of microglia in the brain of patients with sepsis. Neuropathology and applied neurobiology45(3), 278-290.

Duffy, S. S., Keating, B. A., Perera, C. J., Lees, J. G., Tonkin, R. S., Makker, P. G., … & Moalem-Taylor, G. (2019). Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis. Journal of Neuroscience39(12), 2326-2346.

Deussing, M., Götzl, J., Werner, G., Sebastian, L., Kleinberger, G., Parhizkar, S., … & Levin, J. (2019). Opposite microglial phenotypes upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. Nuklearmedizin58(02), P33.

Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., … & Krasemann, S. (2019). Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature neuroscience22(2), 191.

Faustino, J., Chip, S., Derugin, N., Jullienne, A., Hamer, M., Haddad, E., … & Vexler, Z. S. (2019). CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke. Journal of Cerebral Blood Flow & Metabolism, 0271678X18817663.

2018

Katsumoto A, Miranda AS, Butovsky O, Teixeira AL, Ransohoff RM, Lamb BT. Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model. J Neuroinflammation. 2018 Jan 30;15(1):26. doi: 10.1186/s12974-018-1075-y. PMID: 29382353

Lund, H., Pieber, M., Parsa, R., Han, J., Grommisch, D., Ewing, E., … & Överby, A. K. (2018). Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nature communications9(1), 4845.

Rubino, S. J., Mayo, L., Wimmer, I., Siedler, V., Brunner, F., Hametner, S., … & Cox, L. (2018). Acute microglia ablation induces neurodegeneration in the somatosensory system. Nature communications9(1), 4578.

Zrzavy, T., Machado‐Santos, J., Christine, S., Baumgartner, C., Weiner, H. L., Butovsky, O., & Lassmann, H. (2018). Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathology28(6), 791-805.

Butovsky, O., & Weiner, H. L. (2018). Microglial signatures and their role in health and disease. Nature Reviews Neuroscience, 1.

Okunuki, Y., Mukai, R., Pearsall, E. A., Klokman, G., Husain, D., Park, D. H., … & Miller, J. W. (2018). Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proceedings of the National Academy of Sciences115(27), E6264-E6273.

Calcagno, N., Baufeld, C., Madore, C., & Butovsky, O. (2018). TREMendous 2 be social. Immunity48(5), 842-843.

Lund, H., Pieber, M., Parsa, R., Grommisch, D., Ewing, E., Kular, L., … & Needhamsen, M. (2018). Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling. Nature immunology19(5), 1.

Baufeld, C., O’Loughlin, E., Calcagno, N., Madore, C., & Butovsky, O. (2018). Differential contribution of microglia and monocytes in neurodegenerative diseases. Journal of Neural Transmission125(5), 809-826.

O’Loughlin, E., Madore, C., Lassmann, H., & Butovsky, O. (2018). Microglial phenotypes and functions in multiple sclerosis. Cold Spring Harbor perspectives in medicine8(2), a028993.

2017

Drokhlyansky E, Göz Aytürk D, Soh TK, Chrenek R, O’Loughlin E, Madore C, Butovsky O, Cepko CL. The brain parenchyma has a type I interferon response that can limit virus spread. Proc Natl Acad Sci USA. 2017 Jan 3;114(1):E95-E104. doi: 10.1073/pnas.1618157114. Epub 2016 Dec 15. Makker PG, Duffy SS, Lees JG, Perera CJ, Tonkin RS, Butovsky O, 

Park SB, Goldstein D, Moalem-Taylor G. Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PLoS One. 2017 Jan 26;12(1):e0170814. doi: 10.1371/journal.pone.0170814. eCollection 2017.

Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Rep. 2017 Jul;18(7):1186-1198. doi: 10.15252/embr.201743922. Epub 2017 May 8.

Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H. Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis. Brain. 2017 Jul 1;140(7):1900-1913. doi: 10.1093/brain/awx113.

Madore C, Baufeld C, Butovsky O. Microglial confetti party. Nat Neurosci. 2017 May 25;20(6):762-763.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O’Loughlin E, Xu Y, Fanek Z, Greco D, Smith S, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich J, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner F, Litvak V, Holtzman D, Lassmann H, Weiner H, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008

Shi Y, Yamada K, Liddelow S, Smith S, Zhao L, Luo W, Tsai RM, Spina S, Grinberg L, Rojas J, Gallardo G, Sutphen C, Wang K, Roh J, Robinson G, Finn M, Jiang H, Sullivan P, Baufeld C, Wood M, McCue L, Xiong C, Del-Aguila, Morris J, Cruchaga C, Fagan A, Miller B, Boxer A, Seeley W, Butovsky O, Barres BA, Paul, SM, Holtzman, DA. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature 2017 Sep 28;549(7673):523-527. doi: 10.1038/nature24016. Epub 2017 Sep 20.

Zrzavy T, Machado-Santos J, Christine S, Baumgartner C, Weiner HL, Butovsky O, Lassmann H. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathol. 2017 Dec 8. doi: 10.1111/bpa.12583. [Epub ahead of print]. PMID: 29222823

2016

Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ. Dark microglia: A new phenotype predominantly associated with pathological states. Glia. 2016 May;64(5):826-39. doi: 10.1002/glia.22966. Epub 2016 Feb 5.

Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behav Immun. 2016 Oct;57:79-93. doi: 10.1016/j.bbi.2016.06.006. Epub 2016 Jun 11.

Muth C, Schröck K, Madore C, Hartmann K, Fanek Z, Butovsky O, Glatzel M, Krasemann S. Activation of microglia by retroviral infection correlates with transient clearance of prions from the brain but does not change incubation time. Brain Pathol. 2017 Sep;27(5):590-602. doi: 10.1111/bpa.12441. Epub 2016 Nov 21.

2015

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models. J Exp Med. 2015 Mar 9;212(3):287-95.

Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2ry12expression and function in alternatively activated human microglia. Neurol Neuroimmunol Neuroinflamm. 2015 Mar 19;2(2):e80.

Verheijden S, Beckers L, Casazza A, Butovsky O, Mazzone M, Baes M. Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency. Glia. 2015 Sep;63(9):1606-20. doi: 10.1002/glia.22831. Epub 2015 Apr 2.

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov;18(11):1584-93. doi: 10.1038/nn.4132. Epub 2015 Oct 5.

2014

Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan, CE, et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 2014 17:131-143. PMCID: PMC4066672.

Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A.M., Cialic, R., Wu, P.M., Doykan, C.E., Lin, J., Cotleur, A.C., et al. 2014. Differential roles of microglia and monocytes in the inflamed CNS: An EAE study. J Exp Med. 2014 Jul 28;211(8):1533-49. PMCID: PMC4113947. Epub 2014 Jul 7.

Butovsky O, Jedrychowski M, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, Greco D, Wu P, Doykan C, Kiner O, Lawson R, Frosch M, Pochet N, Fatimy R, Krichevsky A, Gygi S, Lassmann H, Berry J, Cudkowicz M, Weiner H. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2014 Nov 7. doi: 10.1002/ana.24304. PMCID: PMC4432483.

2000-2012

Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012 Sep 4; 122(9):3063-87.

Vaknin I, Kunis G, Miller O, Butovsky O, Bukshpan S, Beers DR, Henkel JS, Yoles E, Appel SH, Schwartz M. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. PLoS One. 2011;6(11):e26921. doi: 10.1371/journal.pone.0026921. Epub 2011 Nov 3.

Landa G, Butovsky O, Shoshani J, Schwartz M, Pollack A. Weekly vaccination with Copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degeneration. Current eye research. 2008; 33(11):1011-3.

Butovsky O, Kunis G, Koronyo-Hamaoui M, Schwartz M. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer’s disease model. Eur J Neurosci. 2007 26(2):413-416 

Butovsky O, Bukshpan S, Kunis G, Jung S, Schwartz M. Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markers. Mol Cell Neurosci. 2007 35(3):490-500.

Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J Clin Invest. 2006 116:905-915.

Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E. Landa G, Cohen H and Schwartz M. Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A. 2006 103:11784-11789.

Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar A, Pluchino S, Martino G, Schwartz M. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci. 2006 31:149-160.

Butovsky O, Talpalar AE, Ben-Yaakov K, Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol Cell Neurosci. 2005 29:381-393.

Avidan H, Kipnis J, Butovsky O, Caspi RR, Schwartz M. Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells. Eur J Immunol. 2004 34:3434-3445.

Ibarra A, Hauben E, Butovsky O, Schwartz M. The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats. Eur J Neurosci. 2004 19:2984-2990.

Bomstein Y, Marder JB. Vitner K, Smirnov I, Lisaey G, Butovsky O, Fulga V, Yoles E. Features of skin-coincubated macrophages that promote recovery from spinal cord injury. J Neuroimmunol 2003 142:10-16.

Hauben E, Gothilf A, Cohen A, Butovsky O, Nevo U, Smirnov I, Yoles E, Akselrod S, Schwartz M. Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J Neurosci. 2003 23:8808-8819.

Fisher J, Levkovitch-Verbin H, Schori H, Yoles E, Butovsky O, Kaye JF, Ben-Nun A, Schwartz M. Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies. J Neurosci. 2001 21:136-142.

Butovsky O, Hauben E, Schwartz M. Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation. FASEB J. 2001 15:1065-1067.

Hauben E, Butovsky O, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Leibowitz-Amit R, Pevsner E, Akselrod S, Neeman M, Cohen IR, Schwartz M. Hauben E, Butovsky O, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Leibowitz-Amit R, Pevsner E, Akselrod S, Neeman M, Cohen IR, Schwartz M. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion Neurosci. 2000 Sep 1; 20(17):6421-30.

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