Latest Publications

• Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE August 14, 2024
  No abstract
  Samira Parhizkar
• Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease July 3, 2024
  APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell transcriptomics across APOE variants in both sexes, multiplex flow cytometry and validation in two independent cohorts of APOE4 female carriers with AD, we identify a […]
  Neta Rosenzweig
• Transgenic Targeting of <em>Fcrls</em> Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity June 26, 2024
  Microglia carry out important functions as the resident macrophages of the brain. To study their role in health and disease, the research community needs tools to genetically modify them with maximum completeness in a manner that distinguishes them from closely related cell types, such as monocytes. While currently available tamoxifen-inducible CreERT2 lines can achieve the […]
  Tobias Kaiser
• Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A June 18, 2024
  No abstract
  Anna-Leigh Brown
• Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer's disease mouse models May 8, 2024
  The gut microbiota and microglia play critical roles in Alzheimer's disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in AD. We hypothesize that Bacteroides contributes to AD by modulating microglia. Here we show that administering Bacteroides fragilis to APP/PS1-21 mice increases Aβ plaques in females, modulates cortical amyloid […]
  Caroline Wasén