Latest Publications

• Microglia in the aged brain develop a hypoactive molecular phenotype after surgery December 19, 2024
  CONCLUSIONS: While anesthesia and surgery induce pro-inflammatory changes in the plasma and brain of mice, microglia adopt a homeostatic molecular phenotype following surgery. This effect seems to be more pronounced in aged mice and is transient. These results challenge the prevailing assumption that surgery activates microglia in the aged brain.
  Zhuoran Yin
• Neuroinflammation in Alzheimer disease December 9, 2024
  Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we […]
  Michael T Heneka
• Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner October 10, 2024
  No abstract
  Megan E Bosch
• Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE August 14, 2024
  No abstract
  Samira Parhizkar
• Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease July 3, 2024
  APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell transcriptomics across APOE variants in both sexes, multiplex flow cytometry and validation in two independent cohorts of APOE4 female carriers with AD, we identify a […]
  Neta Rosenzweig