Shooting Themselves in the Foot? Microglia Block “Good” State with ApoE4

Almost 30 years after its discovery as the most prominent risk factor for AD, ApoE continues to serve more questions than answers to the field. As evidenced by the many ApoE-focused presentations at this year’s Alzheimer’s Association International Conference, held July 31 to August 4 in San Diego, California, the brain’s deceptively humble lugger of lipids is still holding mechanistic surprises…

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