Latest Publications

• Neuroinflammation in Alzheimer disease December 9, 2024
  Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we […]
  Michael T Heneka
• Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner October 10, 2024
  No abstract
  Megan E Bosch
• Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE August 14, 2024
  No abstract
  Samira Parhizkar
• Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease July 3, 2024
  APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell transcriptomics across APOE variants in both sexes, multiplex flow cytometry and validation in two independent cohorts of APOE4 female carriers with AD, we identify a […]
  Neta Rosenzweig
• Transgenic Targeting of <em>Fcrls</em> Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity June 26, 2024
  Microglia carry out important functions as the resident macrophages of the brain. To study their role in health and disease, the research community needs tools to genetically modify them with maximum completeness in a manner that distinguishes them from closely related cell types, such as monocytes. While currently available tamoxifen-inducible CreERT2 lines can achieve the […]
  Tobias Kaiser